Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJK0MF)

Drug Name
1-Naphthalen-2-yl-piperazine Drug Info
Synonyms
1-(naphthalen-2-yl)piperazine; 57536-91-1; 1-Naphthalen-2-yl-piperazine; 1-(2-NAPHTHYL)PIPERAZINE; CHEMBL278509; 1-naphthalen-2-ylpiperazine; Oprea1_405543; AC1MC234; SCHEMBL3138664; LWLBVIFUVSUSAY-UHFFFAOYSA-N; ZINC3716177; SBB076290; BDBM50007411; AKOS003591179; MCULE-5668438904
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2760172
TTD Drug ID
DMJK0MF

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Inhibitor [1]
5-HT 1B receptor (HTR1B) TTK8CXU 5HT1B_HUMAN Inhibitor [2]
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Inhibitor [1]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
5-HT 1B receptor (HTR1B) DTT HTR1B 5.781 3.121 6.267 4.986
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
5-HT 1D receptor (HTR1D) DTT HTR1D 3.307 1.263 2.585 5.833
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 2.18E-01 -0.11 -0.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80.
2 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8.