Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK5CJO)

Drug Name

4-(1H-Indol-3-ylmethyl)-phenylamine Drug Info

Synonyms

Benzenamine, 4-(1H-indol-3-ylmethyl)-; CHEMBL364248; 134627-70-6; 4-(1H-indol-3-ylmethyl)aniline; ACMC-20mvfl; 4-(1H-Indol-3-ylmethyl)-phenylamine; AC1N7FQI; SCHEMBL4224120; CTK0F4358; DTXSID30401708; 4-[(1H-Indol-3-yl)methyl]aniline; BDBM50164747

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4301799
CAS Number: CAS 134627-70-6
TTD Drug ID: DMK5CJO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 6 receptor (HTR6)	DTT	HTR6	5.594	5.781	5.271	3.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 6 receptor (HTR6)	DTT	HTR6	1.23E-05	-0.12	-0.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.