Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKAW4P)

Drug Name

(R)-alpha-methylhistamine Drug Info

Synonyms

(R)-alpha-Methylhistamine; CHEBI:73337; r-alpha-methylhistamine; (R)alpha-Me-histamine; CHEMBL268229; (R)-(-)-alpha-methylhistamine; (2R)-1-(1H-imidazol-4-yl)propan-2-amine; 75614-87-8; 1H-Imidazole-4-ethanamine, alpha-methyl-, (alphaR)-; (R)-(-)-4-(2-aminopropyl)imidazole; (2R)-1-(3H-imidazol-4-yl)propan-2-amine; (2R)-1-(1H-imidazol-5-yl)propan-2-amine; Alpha-Methylhistamine-R; C6H11N3; [3H]-R-alpha-Methylhistamine; (R)-[3H]alpha-methylhistamine; [3H](R)-alpha-methylhistamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 156615
ChEBI ID: CHEBI:73337
CAS Number: CAS 75614-87-8
TTD Drug ID: DMKAW4P

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Agonist	[2]
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Agonist	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H4 receptor (H4R)	DTT	HRH4	5.238	4.933	4.347	4.022
Histamine H3 receptor (H3R)	DTT	HRH3	3.225	3.399	3.17	3.027

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H3 receptor (H3R)	DTT	HRH3	3.62E-02	-0.09	-0.22

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1237).
2	The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.
3	Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.