Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKH8TC)

Drug Name

Etisulergine Drug Info

Synonyms

Etisulergine; UNII-28N73Q6O7Y; 64795-23-9; 28N73Q6O7Y; Etisulerginum; Etisulergina; etisulergine[inn]; Etisulergine [INN]; Etisulerginum [INN-Latin]; Etisulergina [INN-Spanish]; CQ 32-084; AC1L2AKJ; AC1Q6V8T; SCHEMBL219311; CHEMBL38992; BDBM50225361; 72782-54-8 (mono-hydrochloride)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 68847
CAS Number: CAS 64795-23-9
TTD Drug ID: DMKH8TC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Inhibitor	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
5-HT 1D receptor (HTR1D)	DTT	HTR1D	3.307	1.263	2.585	5.833

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-... J Med Chem. 1985 Oct;28(10):1540-2.