Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKHMS4)

Drug Name

NSC-119910 Drug Info

Synonyms

NSC119910; NSC-119910; CHEMBL487046; Gbetagamma Modulator I, M119; 2-(4,5,6-Trihydroxy-3-oxo-3H-xanthen-9-yl)-cyclohexane-1-carboxylic acid; AC1L6U1C; SCHEMBL2778459; cid_274122; SCHEMBL16556406; BDBM50246208; NCI60_000471; MLS-0111618.0001; 2-(4,6-trihydroxy-3-oxo-3H-xanthen-9-yl)cyclohexanecarboxylic acid; 2-(3,4,5-trihydroxy-6-oxo-xanthen-9-yl)cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 2-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)-; 2-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)cyclohexanecarboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Cardiac failure	BD10-BD13	Investigative	[1]

Cross-matching ID

PubChem CID: 274122
CAS Number: CAS 500533-94-8
TTD Drug ID: DMKHMS4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 70 (HSP70)	TTHYBIX	HS71A_HUMAN; HS71B_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cardiac failure

ICD Disease Classification

BD10-BD13

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Heat shock protein 70 (HSP70)	DTT	HSPA1A; HSPA1B	1.03E-20	0.32	1.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.