Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKJQWR)

Drug Name

FR-230481 Drug Info

Synonyms

FR-230481; CHEMBL167991; BDBM50110571; FR230481; Naphthalene-1-sulfonic acid [2-(4-{[(1-hydroxy-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-amino]-methyl}-piperidin-1-yl)-ethyl]-amide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10030142
TTD Drug ID: DMKJQWR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuropeptide Y receptor type 5 (NPY5R)	TTY6EWA	NPY5R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neuropeptide Y receptor type 5 (NPY5R)	DTT	NPY5R	6.192	6.174	6.582	6.385

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neuropeptide Y receptor type 5 (NPY5R)	DTT	NPY5R	7.49E-01	1.19E-02	0.03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802.