Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKTA5R)

• Drug Name: O-methyldauricine Drug Info
• Synonyms: O-Methyldauricine; 2202-17-7; O,O-Dimethylcuspidaline; O,O-Dimethyldauricinoline; CHEMBL501861; Dauricine, O-methyl- (6CI,7CI,8CI); Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-((4-(2-methoxy-5-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-2-methyl-, (R-(R*,R*))-; Dauricine, O-methyl-; AC1L44JA; DTXSID50176486; C39H46N2O6; 8192AH; BDBM50292469; ZINC42805235; LS-85912; AN-50531; 202M177; Q-100278

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 200521
  CAS Number: CAS 2202-17-7
  TTD Drug ID: DMKTA5R

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

References

• [1] Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.