Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKUETX)

Drug Name
CGS 8515 Drug Info
Synonyms
114832-13-2; CGS-8515; Methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate; Benzoic acid,2-[(3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino]-, methyl ester; methyl 2-[(3,4-dioxonaphthalen-1-yl)amino]benzoate; AC1L4TWI; AC1Q5ZBK; cgs8515; ACMC-1C4N1; SCHEMBL3273068; CTK4A8934; DTXSID80150875; methyl 2-[(3,4-dioxo-3,4-dihydronaphthalen-1-yl)amino]benzoate; Benzoic acid, 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)-, methyl ester
Cross-matching ID
PubChem CID
163944
CAS Number
CAS 114832-13-2
TTD Drug ID
DMKUETX

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.966 5.133 5.358 6.128
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 7.42E-01 -0.18 -0.25
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 1.25E-03 0.43 0.63
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. Biochim Biophys Acta. 1988 Apr 15;959(3):332-42.