General Information of Drug (ID: DMKVA6Z)

Drug Name
FE 999011 Drug Info
Synonyms
Tle-Pro-CN; UNII-I17T1J33X6; CHEMBL363250; I17T1J33X6; FE-999011; 171092-64-1; SCHEMBL369343; fe999011; BDBM50151003; ZINC53122800; 2-Pyrrolidinecarbonitrile, 1-(2-amino-3,3-dimethyl-1-oxobutyl)-, (S-(R*,R*))-; 2-Pyrrolidinecarbonitrile, 1-((2S)-2-amino-3,3-dimethyl-1-oxobutyl)-, (2S)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10130510
CAS Number
CAS 171092-64-1
TTD Drug ID
DMKVA6Z

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dipeptidyl peptidase 4 (DPP-4) DTT DPP4 4.995 4.926 7.852 8.358
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dipeptidyl peptidase 4 (DPP-4) DTT DPP4 9.54E-01 -0.27 -1.85
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes. 2002 May;51(5):1461-9.