Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKXNP0)

Drug Name

6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine Drug Info

Synonyms

CHEMBL50379; 6-(2-phenylsulfanylethyl)pteridine-2,4-diamine; AC1L9YC2; 6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine; BDBM50127151; 2,4-Pteridinediamine, 6-[2-(phenylthio)ethyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 504032
TTD Drug ID: DMKXNP0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Polypeptide deformylase (PDF)	DTT	PDF	8.87E-16	-0.54	-0.86

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36.