Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML0B97)

Drug Name

HOE-694 Drug Info

Synonyms

141923-47-9; 3-METHYLSULFONYL-4-PIPERIDIN-1-YLBENZOYL GUANIDINE; HOE694; AC1L3XEA; CHEMBL62231; SCHEMBL3906516; CTK4C2847; ZINC3915646; AKOS030541973; KB-236684; TX-016775; 3-methylsulphonyl-4-piperidinobenzoyl-guanidine

Indication

Disease Entry	ICD 11	Status	REF
Heart arrhythmia	BC65	Terminated	[1]

Cross-matching ID

PubChem CID: 123841
TTD Drug ID: DML0B97

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium/hydrogen exchanger 1 (SLC9A1)	TTGSEFH	SL9A1_HUMAN	Inhibitor	[2]
Sodium/hydrogen exchanger 3 (SLC9A3)	TTFZVPO	SL9A3_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Sodium/hydrogen exchanger 3 (SLC9A3)	DTT	SLC9A3	2.202	2.678	4.154	2.406

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Heart arrhythmia

ICD Disease Classification

BC65

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Sodium/hydrogen exchanger 3 (SLC9A3)	DTT	SLC9A3	6.83E-01	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Effect of Hoe 694, a novel Na(+)-H+ exchange inhibitor, on intracellular pH regulation in the guinea-pig ventricular myocyte. Br J Pharmacol. 1996 Aug;118(8):1905-12.
2	(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34.