Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML5FX2)

Drug Name
MDX-018 Drug Info
Synonyms HuMax-IL8; HuMax-Inflam; Anti-inflammatory antibody, Medarex/Genmab; Anti-inflammatory therapeutic, Genmab/Medarex
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DML5FX2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin-8 (IL8) DTT CXCL8 4.892 4.17 4.65 3.807
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Autoimmune diabetes
ICD Disease Classification 5A10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin-8 (IL8) DTT CXCL8 9.05E-17 2.09 3.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of Genmab.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Company report (Genmab)