Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML5QFZ)

Drug Name

GNF-PF-2857 Drug Info

Synonyms

GNF-PF-2857; CHEMBL217665; ChemDiv1_019259; N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine; N-[4-(4-methylpiperazin-1-yl)phenyl]quinolin-4-amine; AC1NCZHO; Oprea1_484208; SCHEMBL7129284; HMS641L09; ZINC1507915; BDBM50196110; AKOS024359777; MCULE-1778420008; ST50989409; [4-(4-methylpiperazinyl)phenyl]-4-quinolylamine; SR-01000394477; SR-01000394477-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4567175
ChEBI ID: CHEMBL217665
TTD Drug ID: DML5QFZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63.