Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLV0PQ)

Drug Name

1-(2-allylphenoxy)-3-morpholinopropan-2-ol Drug Info

Synonyms

CHEMBL1083667; 1-morpholin-4-yl-3-(2-prop-2-enylphenoxy)propan-2-ol; BAS 00134198; AC1MCHI5; 1-(2-allylphenoxy)-3-morpholinopropan-2-ol; Oprea1_670642; Oprea1_634560; MLS001143833; MolPort-001-916-053; HMS2803P24; STK843731; BDBM50318978; AKOS016050431; AKOS000525780; MCULE-7265762065; SMR000473272; ST50000343; EN300-241692; 1-(2-allylphenoxy)-3-morpholin-4-ylpropan-2-ol; 1-(2-Allyl-phenoxy)-3-morpholin-4-yl-propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2769774
TTD Drug ID: DMLV0PQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor beta-3 (ADRB3)	DTT	ADRB3	2.392	2.655	2.278	1.982
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.09	5.67	5.558	5.603

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-3 (ADRB3)	DTT	ADRB3	7.81E-01	0.02	0.16

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404.