Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLW651)

Drug Name

4-amino-N-p-tolylbenzenesulfonamide Drug Info

Synonyms

4-Amino-N-(4-methylphenyl)benzenesulfonamide; 16803-95-5; 4-Amino-N-(p-tolyl)benzenesulfonamide; QXIZWXNTAVXJNC-UHFFFAOYSA-N; Benzenesulfonamide, 4-amino-N-(4-methylphenyl)-; AC1LC9K2; Oprea1_140477; CHEMBL389286; SCHEMBL2240008; CTK0E5316; DTXSID50341293; MolPort-002-788-929; ZINC265634; ALBB-005339; ZX-AN005271; BBL008295; STK288097; 4-Amino-N-p-tolyl-benzenesulfonamide; AKOS000151276; MCULE-6336197788; SEL11434898; TR-041978; TR-058746; AB0221486; ST45130422; R4223; EU-0099855; [(4-aminophenyl)sulfonyl](4-methylphenyl)amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 572102
CAS Number: CAS 16803-95-5
TTD Drug ID: DMLW651

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21.