Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLW9HG)

• Drug Name: Tildrakizumab Drug Info
• Synonyms: UNII-DEW6X41BEK; DEW6X41BEK; Tildrakizumab [USAN:INN]; SCH 900222

Indication

Disease Entry	ICD 11	Status	REF
Plaque psoriasis	EA90.0	Approved	[1]

• Cross-matching ID: TTD Drug ID: DMLW9HG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-23 (IL23)	TTC1GLB	IL23A_HUMAN	Modulator	[1]
Interleukin-37 (IL37)	TTQTX98	IL37_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Plaque psoriasis
• ICD Disease Classification: EA90.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-23 (IL23)	DTT	IL23A	5.37E-01	-0.1	-0.42

References

• [1] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)