Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMDNA8)

Drug Name

2-(3-Mercapto-propyl)-pentanedioic acid Drug Info

Synonyms

2-(3-mercaptopropyl)pentanedioic acid; 2-MPPA; 2-(3-sulfanylpropyl)pentanedioic Acid; 254737-29-6; CHEMBL303352; Pentanedioic acid, 2-(3-mercaptopropyl)-; 2-[3-mercaptopropyl]pentanedioic acid; GPI 5693; SCHEMBL787800; CTK0J4030; BDBM17755; FNLNSQHJKVQCBP-UHFFFAOYSA-N; MolPort-035-765-922; pentanedioic acid analogue, (RS)-3; AKOS024458465

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10198171
CAS Number: CAS 254737-29-6
TTD Drug ID: DMMDNA8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate carboxypeptidase II (GCPII)	TT9G4N0	FOLH1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	6.894	4.758	5.651	9.837

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	1.40E-09	2.08	2.21

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96.