Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMF1HX)

Drug Name

ISOCONAZOLE Drug Info

Synonyms

Isoconazole; 27523-40-6; Isoconazolum; Isoconazol; Travogen; Isoconazol [INN-Spanish]; Isoconazolum [INN-Latin]; EINECS 248-508-3; CHEBI:83667; MPIPASJGOJYODL-UHFFFAOYSA-N; 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole; 1-(2,4-Dichloro-beta-((2,6-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2-(2,4-Dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)1H-imidazole; DSSTox_CID_25447; DSSTox_RID_80886; DSSTox_GSID_45447; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3760
ChEBI ID: CHEBI:83667
CAS Number: CAS 27523-40-6
TTD Drug ID: DMMF1HX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 17-alpha-monooxygenase (S17AH)	DTT	CYP17A1	6.213	5.615	6.895	6.025

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 17-alpha-monooxygenase (S17AH)	DTT	CYP17A1	6.87E-01	0.07	0.21

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. J Med Chem. 2003 Jun 5;46(12):2345-51.