Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMO6P0)

Drug Name

Tifacogin Drug Info

Synonyms

LACI; SC-59735; TFP-561; LACI, Pharmacia/Chiron; LACI, Searle/Chiron; Lipoprotein associated coagulation inhibitor, Pharmacia/Chiron;Lipoprotein associated coagulation inhibitor, Searle/Chiron; RTFPI, Pharmacia/Chiron; RTFPI, Searle/Chiron; Tissue factor pathway inhibitor, Pharmacia/Chiron; Tissue factor pathway inhibitor, Searle/Chiron

Indication

Disease Entry	ICD 11	Status	REF
Sepsis	1G40-1G41	Phase 3	[1]

Cross-matching ID

PubChem CID: 961320
CAS Number: CAS 73325-61-8
TTD Drug ID: DMMO6P0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tissue factor pathway inhibitor (TFPI)	TT068JH	TFPI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tissue factor pathway inhibitor (TFPI)	DTT	TFPI	6.785	5.293	7.315	5.975

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Sepsis

ICD Disease Classification

1G40-1G41

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tissue factor pathway inhibitor (TFPI)	DTT	TFPI	1.27E-08	0.14	0.84

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003 Jul 9;290(2):238-47.