General Information of Drug (ID: DMMU1CQ)

Drug Name
2-amino-2-(3-chloro-4-fluorophenyl)acetic acid Drug Info
Synonyms
261762-99-6; 2-amino-2-(3-chloro-4-fluorophenyl)acetic acid; 3-Chloro-4-fluoro-DL-phenylglycine; C8H7ClFNO2; CHEMBL203905; amino(3-chloro-4-fluorophenyl)acetic acid; AC1MCND8; SCHEMBL8196588; KS-00000ZXX; CTK8F0591; DTXSID40378674; MolPort-000-153-073; JRD-1093; SBB093187; BDBM50179692; 8653AD; 2-(3-Chloro-4-fluorophenyl)glycine; MFCD01631397; AKOS032962888; AKOS015907725; MCULE-4108995551; RTR-011871; PS-6305; SY044823; TR-011871; ST51041478; FT-0676194; MFCD01631397 (95%); C-5924
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2773727
CAS Number
CAS 261762-99-6
TTD Drug ID
DMMU1CQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.