Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMU6BJ)

Drug Name

Sodium bicarbonate Drug Info

Synonyms

Acidosan; Colovage; Glycoprep; Golytely; Jusonin; Meylon; Natriumhydrogenkarbonat; Natron; Neut; Nulytely; Soludal; BSS plus; Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; Gripe water; Lithium bicarbonate; Monosodium hydrogen carbonate; Natrii hydrogencarbonas; Natrium bicarbonicum; Natrium hydrogencarbonicum; Natrum bicarbonicum; Sandoz sodium bicarbonate; Sel De vichy; Soda Mint; Sodium acid carbonate; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Sodium bicarbonate solution; Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; NaHCO3; Bicarbonate, Sodium; Carbonic acid, monosodium salt; Co-lav; Col-evac; Go-evac; Hema BP-38; Hydrogen Carbonate, Sodium; Meylon (TN); Neut (TN); Peg-lyte; Soda (van); Soda, Baking; Sodium bicarbonate [USAN:JAN]; Carbonic acid sodium salt (1:1); E-Z-EM Prep Lyte; Sodium bicarbonate (1:1); Sodium bicarbonate (JP15/USP); Sodium carbonate (Na(HCO3)); 800 Sodium Bicarbonate Powder

Indication

Disease Entry	ICD 11	Status	REF
Metabolic acidosis	5C73	Approved	[1]

Therapeutic Class

Antidiarrheals

Cross-matching ID

PubChem CID: 516892
ChEBI ID: CHEBI:32139
CAS Number: CAS 144-55-8
TTD Drug ID: DMMU6BJ
VARIDT Drug ID: DR00038
ACDINA Drug ID: D00629

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	TTZPWGN	CAC1H_HUMAN	Blocker	[2]
Voltage-gated potassium channel Kv4.3 (KCND3)	TTPLQO0	KCND3_HUMAN	Blocker	[3]

------------------------------------------------------------------------------------

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	DTW40Z7	S4A8_HUMAN	Approved	[4]
Sodium-driven chloride bicarbonate exchanger (SLC4A10)	DT7RYVF	S4A10_HUMAN	Approved	[5]
Anion exchange protein 4 (SLC4A9)	DTSQY0W	B3A4_HUMAN	Approved	[6]
Sodium bicarbonate cotransporter 3 (SLC4A7)	DT03V27	S4A7_HUMAN	Approved	[4]
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)	DTCL4P8	S4A5_HUMAN	Approved	[4]
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	DTWDEIL	S4A4_HUMAN	Approved	[7]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	DTT	CACNA1H	3.485	2.536	3.524	3.511
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	DTP	NBCe1	7.157	7.563	8.29	7.935
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	DTP	NDCBE	0.926	1.433	1.585	5.19
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)	DTP	NBCe2	4.517	3.902	3.995	5.592
Sodium-driven chloride bicarbonate exchanger (SLC4A10)	DTP	NCBE	4.336	3.878	3.536	3.632
Sodium bicarbonate cotransporter 3 (SLC4A7)	DTP	NBC3	4.158	4.797	5.333	6.207

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Metabolic acidosis

ICD Disease Classification

5C73

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	DTT	CACNA1H	1.31E-04	-0.76	-2.12
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	DTP	NBCe1	3.17E-01	-1.76E-01	-2.01E-01
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	DTP	NDCBE	1.00E-01	-3.40E-01	-4.11E-01
Anion exchange protein 4 (SLC4A9)	DTP	AE4	2.54E-01	-2.66E-02	-1.13E-01
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)	DTP	NBCe2	8.63E-01	-6.11E-02	-5.24E-01
Sodium-driven chloride bicarbonate exchanger (SLC4A10)	DTP	NCBE	1.67E-01	-1.44E-01	-9.30E-01
Sodium bicarbonate cotransporter 3 (SLC4A7)	DTP	NBC3	4.23E-03	5.04E-01	1.46E+00

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4507).
2	Acute renal failure. Clin Evid (Online). 2008 Sep 3;2008. pii: 2001.
3	Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila). 2009 Jan;47(1):14-23.
4	The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60.
5	Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90.
6	A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011.
7	The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8.