Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMU6WQ)

Drug Name

Tetrahydro-pyrimidin-2-ylideneamine Drug Info

Synonyms

1,4,5,6-tetrahydropyrimidin-2-amine; 41078-65-3; 1,4,5,6-tetrahydro-2-Pyrimidinamine; 1,4,5,6-tetrahydro-pyrimidin-2-ylamine; 2-amino-1,4,5,6-tetrahydropyrimidine; CHEMBL158626; Tetrahydro-pyrimidin-2-ylideneamine; Tetrahydropyrimidinimin; 2(1h)-pyrimidinimine; AC1MMKIU; tetrahydro-2(1H)-pyrimidinimine; DTXSID90391075; PEHDFSFYZKSKGH-UHFFFAOYSA-N; ZINC1728936; hexahydro-pyrimidin-2-ylidene-amine; BDBM50049248; AKOS024618750; AKOS011559938; MCULE-1407334516; 2-amino-3,4,5,6-tetrahydropyrimidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3287412
CAS Number: CAS 41078-65-3
TTD Drug ID: DMMU6WQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72.