Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN2EI1)

Drug Name
bis-triazole derivative 10 Drug Info
Synonyms CHEMBL2016873; bis-triazole derivative 10; GTPL6537; SCHEMBL15308834
Indication
Disease Entry ICD 11 Status REF
Otitis media AA80-AB0Z Clinical trial [1]
Cross-matching ID
PubChem CID
56599309
ChEBI ID
CHEMBL2016873
TTD Drug ID
DMN2EI1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasminogen (PLG) TTP86E2 PLMN_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Plasminogen (PLG) DTT PLG 11.754 0.848 8.393 2.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Otitis media
ICD Disease Classification AA80-AB0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Plasminogen (PLG) DTT PLG 8.61E-01 -0.01 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6537).
2 A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem. 2012 Feb 9;55(3):1171-80.