Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN5SL6)

Drug Name

1-(1-phenylethylidene)thiosemicarbazide Drug Info

Synonyms

CHEMBL256868; Acetophenone thiosemicarbazone; AC1NSE5V; SCHEMBL17666972; MolPort-000-248-706; ACETOPHENONE-THIOSEMICARBAZONE; BDBM50376200; ZINC13655939; AKOS002388568; AKOS002238721; [(Z)-1-phenylethylideneamino]thiourea; [(Z)-(1-phenylethylidene)amino]thiourea; KB-106912; ST50101590; (z)-2-(1-phenylethylidene)hydrazinecarbothioamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5359703
TTD Drug ID: DMN5SL6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102.