Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMND3AB)

Drug Name
Asimadoline Drug Info
Synonyms Asimadoline [INN]; EMD 61753; N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide
Indication
Disease Entry ICD 11 Status REF
Diarrhea-predominant irritable bowel syndrome DD91.01 Phase 3 [1]
Pruritus EC90 Phase 2 [2]
Cross-matching ID
PubChem CID
179340
CAS Number
CAS 153205-46-0
TTD Drug ID
DMND3AB
VARIDT Drug ID
DR01267

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor kappa (OPRK1) TTQW87Y OPRK_HUMAN Agonist [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Phase 3 [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Opioid receptor kappa (OPRK1) DTT OPRK1 5.533 5.372 5.703 5.632
P-glycoprotein 1 (ABCB1) DTP P-GP 7.009 6.988 7.442 8.135
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Diarrhea-predominant irritable bowel syndrome
ICD Disease Classification DD91.01
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Opioid receptor kappa (OPRK1) DTT OPRK1 9.17E-01 0.04 0.1
P-glycoprotein 1 (ABCB1) DTP P-GP 9.26E-01 -3.59E-03 -1.34E-02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.