Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNO5UE)

Drug Name

Labetuzumab I-131 Drug Info

Synonyms

IMMU-111

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carcinoembryonic antigen CEA (CD66e)	TTY6DTE	CEAM5_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carcinoembryonic antigen CEA (CD66e)	DTT	CEACAM5	5.812	11.49	6.112	6.957

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Colorectal cancer

ICD Disease Classification

2B91.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carcinoembryonic antigen CEA (CD66e)	DTT	CEACAM5	6.68E-91	0.29	1.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Phase II trial of carcinoembryonic antigen radioimmunotherapy with 131I-labetuzumab after salvage resection of colorectal metastases in the liver: five-year safety and efficacy results. J Clin Oncol.2005 Sep 20;23(27):6763-70.
2	National Cancer Institute Drug Dictionary (drug id 692828).