Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNOUSV)

Drug Name

3,3-diphenylpropan-1-amine Drug Info

Synonyms

3,3-Diphenylpropylamine; 5586-73-2; 3,3-diphenylpropan-1-amine; UNII-C31E561S64; KISZTEOELCMZPY-UHFFFAOYSA-N; Benzenepropanamine, .gamma.-phenyl-; MFCD00008202; C31E561S64; 3-3-Diphenylpropylamine; 3,3-diphenylpropylamine e; 3,3-diphenylpropan-1-amin; EINECS 226-984-3; NSC137832; NSC 137832; ACMC-209lpx; 3.3-diphenylpropylamine; 3,3 Diphenylpropylamine; 3,3-diphenyl-propylamine; 3,3-diphenyl propylamine; EC 226-984-3; (3,3-diphenylpropyl)amine; AC1Q1HZ2; AC1L2XY3; TimTec1_004202; 3,3-Diphenyl-1-propanamine; Propylamine, 3,3-dipheny

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 79698
CAS Number: CAS 5586-73-2
TTD Drug ID: DMNOUSV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H1 receptor (H1R)	DTT	HRH1	5.972	5.7	5.816	6.002

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504.