Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMO1IHL)

Drug Name

PMID17935984C1 Drug Info

Synonyms

CHEBI:45030; 1you; AC1LCVYP; GTPL6526; BDBM50224854; DB08388

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Clinical trial	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-13 (MMP-13)	TTHY57M	MMP13_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-13 (MMP-13)	DTT	MMP13	1.263	4.603	2.138	1.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Pain

ICD Disease Classification

MG30-MG3Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Matrix metalloproteinase-13 (MMP-13)	DTT	MMP13	1.25E-03	0.76	1.3

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34.