Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMO50U2)

Drug Name

Naratriptan Drug Info

Synonyms

Colatan; Naramig; Naratriptanum; Amerge (TN); Naramig (TN); Naratriptan (INN); Amerge, Naramig,Naratriptan; N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide; N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide; N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Headache	8A80-8A84	Approved	[1]
Migraine	8A80	Approved	[2]
Migraine disorder		Approved	[1]

Therapeutic Class

Vasoconstrictor Agents

Cross-matching ID

PubChem CID: 4440
ChEBI ID: CHEBI:7478
CAS Number: CAS 121679-13-8
TTD Drug ID: DMO50U2
VARIDT Drug ID: DR01282
INTEDE Drug ID: DR1131
ACDINA Drug ID: D00457

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1B receptor (HTR1B)	TTK8CXU	5HT1B_HUMAN	Agonist	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Approved	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Monoamine oxidase type A (MAO-A)	DERE4TU	AOFA_HUMAN	Approved	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1B receptor (HTR1B)	DTT	HTR1B	5.781	3.121	6.267	4.986
Organic cation transporter 1 (SLC22A1)	DTP	`OCT1	10.261	4.162	4.07	3.797
Monoamine oxidase type A (MAO-A)	DME	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Headache

ICD Disease Classification

8A80-8A84

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1B receptor (HTR1B)	DTT	HTR1B	3.68E-03	0.16	0.92
Organic cation transporter 1 (SLC22A1)	DTP	SLC22A1	5.15E-01	1.61E-02	7.93E-02
Monoamine oxidase type A (MAO-A)	DME	MAOA	4.12E-01	-2.32E-02	-8.23E-02

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Naratriptan FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 45).
3	Triptans in pregnancy. Ther Drug Monit. 2008 Feb;30(1):5-9.
4	OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41.
5	Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother. 2000 Mar;1(3):391-404.