Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOG1LX)

Drug Name

IGN-101 Drug Info

Synonyms

Cancer vaccine, Igeneon; Anti-EpCam murine monoclonal antibody 17-A carcinoma vaccine; Aluminum-adsorbed murine monoclonal antibody 17-1A (edrecolomab) vaccine antigen (cancer), Igeneon

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Discontinued in Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMOG1LX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor-associated calcium signal transducer 1 (EPCAM)	TTZ8WH4	EPCAM_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tumor-associated calcium signal transducer 1 (EPCAM)	DTT	EPCAM	4.307	10.904	9.628	10.804

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Colorectal cancer

ICD Disease Classification

2B91.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor-associated calcium signal transducer 1 (EPCAM)	DTT	EPCAM	5.99E-02	-0.11	-1.11

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013809)
2	Drug evaluation: IGN-101--an anti-EpCAM murine antibody vaccine for cancer. Curr Opin Mol Ther. 2006 Aug;8(4):358-65.