Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOHSY0)

Drug Name

5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine Drug Info

Synonyms

5'-deoxy-5'-(dimethylamino)-8-methyladenosine; SCHEMBL955366; 5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine; CHEMBL516214; AdoMet substrate analogue, 23a; BDBM28452; BDRUNDKEQQVJJG-QYVSTXNMSA-N; (2R,3R,4S,5R)-2-(6-amino-8-methyl-9H-purin-9-yl)-5-[(dimethylamino)methyl]oxolane-3,4-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 25231308
TTD Drug ID: DMOHSY0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	6.747	6.763	7.033	6.593

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.