Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOIP7R)

• Drug Name: Flesinoxan Drug Info
• Synonyms: Flesinoxan hydrochloride; DU-29373

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Discontinued in Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 57347
  CAS Number: CAS 98206-10-1
  TTD Drug ID: DMOIP7R
  VARIDT Drug ID: DR01350

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Agonist	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Discontinued in Phase 3	[3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
P-glycoprotein 1 (ABCB1)	DTP	P-GP	7.009	6.988	7.442	8.135

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Anxiety disorder
• ICD Disease Classification: 6B00-6B0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51
P-glycoprotein 1 (ABCB1)	DTP	P-GP	1.08E-01	-2.87E-01	-5.57E-01
P-glycoprotein 1 (ABCB1)	DTP	P-GP	2.05E-01	1.60E-01	1.37E+00

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1).
• [2] Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. Eur Neuropsychopharmacol. 1999 Sep;9(5):427-40.
• [3] Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. Eur J Pharm Sci. 2001 Aug;14(1):81-6.