Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOMAXJ)

Drug Name

1-(2-Phenoxy-ethyl)-1H-imidazole Drug Info

Synonyms

CHEMBL284827; 1-(2-Phenoxy-ethyl)-1H-imidazole; 1H-Imidazole, 1-(2-phenoxyethyl)-; 1-(2-Phenoxyethyl)imidazole; SCHEMBL10370478; INUSBZKZIYQSRM-UHFFFAOYSA-N; ZINC26473891; BDBM50025988; AKOS002677376

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 13569172
TTD Drug ID: DMOMAXJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32.