Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP6DBX)

Drug Name

GNF-PF-2307 Drug Info

Synonyms

3-Phenyl-5H-indeno[1,2-c]pyridazin-5-one; GNF-PF-2307; NSC663883; 77152-22-8; CHEMBL421088; 3-phenylindeno[1,2-c]pyridazin-5-one; 5H-Indeno[1,2-c]pyridazin-5-one, 3-phenyl-; AC1Q6KMU; AC1L8E6X; Oprea1_571099; MLS000539984; cid_379337; Aza-heterocyclic Derivative, 1b; KS-00001QSP; CTK2G0333; BDBM19164; DTXSID40327521; MolPort-002-851-051; HMS2177H12; ZINC1383534; STK336084; AKOS005075114; NSC-663883; MCULE-8078785196; SMR000125442; NCI60_021916; 3-(Phenyl)-5H-indeno[1,2-c]pyridazin-5-one; SR-01000694335; 10K-057

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 379337
CAS Number: CAS 77152-22-8
TTD Drug ID: DMP6DBX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	9.315	6.241	6.761	5.625

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	8.95E-01	1.34E-02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.