Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPCUN5)

Drug Name
MT-110 Drug Info
Synonyms MuS110; Bispecific EpCAM/CD3 antibody (cancer), Micromet
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMPCUN5

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
T-cell surface glycoprotein CD3 epsilon (CD3E) TTZAT79 CD3E_HUMAN Not Available [1]
T-cell surface glycoprotein CD3 gamma (CD3G) TTV3XPL CD3G_HUMAN Not Available [1]
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
T-cell surface glycoprotein CD3 epsilon (CD3E) DTT CD3E 6.751 6.684 6.296 7.06
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 4.307 10.904 9.628 10.804
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
T-cell surface glycoprotein CD3 epsilon (CD3E) DTT CD3E 1.53E-06 -0.93 -1.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74.