Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPLHEY)

Drug Name

1-(2-Hydroxy-5-nitro-phenyl)-3-phenyl-urea Drug Info

Synonyms

CHEMBL24912; 1-(2-hydroxy-5-nitro-phenyl)-3-phenyl-urea; SCHEMBL5595042; MHNNUSRLYWTBJF-UHFFFAOYSA-N; ZINC13559606; BDBM50140790; AKOS016618380; N-[5-nitro-2-hydroxyphenyl]-N'-phenylurea; N-[5-nitro-2-hydroxyphenyl]-N'-phenyl urea

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11818139
TTD Drug ID: DMPLHEY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 2 (CXCR2)	TT30C9G	CXCR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-X-C chemokine receptor type 2 (CXCR2)	DTT	CXCR2	2.722	1.202	1.202	0.848

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-X-C chemokine receptor type 2 (CXCR2)	DTT	CXCR2	8.82E-01	-0.23	-0.21
C-X-C chemokine receptor type 2 (CXCR2)	DTT	CXCR2	1.34E-01	0.21	0.19

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21.