Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ509J)

• Drug Name: Alicaforsen Drug Info
• Synonyms: Alicaforsen [INN]; ISIS 2302; ISIS-2302; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)

Indication

Disease Entry	ICD 11	Status	REF
Lleum inflammation	1A40.0	Phase 3	[1]
Crohn disease	DD70	Phase 2	[2]
Ulcerative colitis	DD71	Phase 2	[2]

• Therapeutic Class: Antisense
• Cross-matching ID:
  PubChem CID: 16197725
  CAS Number: CAS 185229-68-9
  TTD Drug ID: DMQ509J

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ICAM1 messenger RNA (ICAM1 mRNA)	TTA1L39	ICAM1_HUMAN	Not Available	[3]
Intercellular adhesion molecule ICAM-1 (ICAM1)	TTCT6F7	ICAM1_HUMAN	Antagonist	[4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	7.993	5.81	6.662	5.926
ICAM1 messenger RNA (ICAM1 mRNA)	DTT	ICAM1	7.993	5.81	6.662	5.926

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Lleum inflammation
• ICD Disease Classification: 1A40.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	9.18E-01	0.04	0.07

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
• [3] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)