Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQFSI5)

Drug Name

Retagliptin Drug Info

Synonyms

DPP4 inhibitors, Shanghai Hengrui Pharmaceutical Co Ltd; SHR-1039; SHR-1040; DPPIV inhibitors (diabetes), Shanghai Hengrui Pharmaceutical Co Ltd; Dipeptidyl peptidase IV inhibitors (diabetes), Shanghai Hengrui Pharmaceutical Co Ltd

Indication

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Investigative	[1]

Cross-matching ID

PubChem CID: 44193830
CAS Number: CAS 1174122-54-3
TTD Drug ID: DMQFSI5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dipeptidyl peptidase 4 (DPP-4)	TTDIGC1	DPP4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	4.995	4.926	7.852	8.358

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Non-insulin dependent diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	9.54E-01	-0.27	-1.85

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612).