Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQIC3L)

Drug Name

2-aminopyridine Drug Info

Synonyms

2-AMINOPYRIDINE; 504-29-0; pyridin-2-amine; 2-Pyridinamine; 2-Pyridylamine; Aminopyridine; Pyridinamine; o-Aminopyridine; 2-aminopyridin; 2-Aminopryidine; Amino-2 pyridine; Pyridine, 2-amino-; 1,2-Dihydro-2-iminopyridine; alpha-Pyridylamine; alpha-Pyridinamine; 2-Pyridinylnitrene; alpha-Aminopyridine; Pyridin-2-ylamine; NSC 431; UNII-WSX981HEWU; 2-pyridinylamine; 2-amino pyridine; Pyridine, amino-; pyridin-2-yl-amine; .beta.-Pyridylamine; .alpha.-Pyridylamine; .alpha.-Pyridinamine; CCRIS 4747; .alpha.-Aminopyridine; 26445-05-6; HSDB 206

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10439
CAS Number: CAS 504-29-0
TTD Drug ID: DMQIC3L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors. J Med Chem. 2009 Jul 23;52(14):4533-7.