Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQMV1B)

Drug Name
Adalimumab Drug Info
Synonyms Humira; Adalimumab (genetical recombination); Humira (TN); Adalimumab (USAN/INN); Adalimumab (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Approved [1]
Hidradenitis suppurativa ED92.0 Approved [2]
Mucositis CA00 Approved [3]
Psoriatic arthritis FA21 Approved [4]
Pyoderma gangrenosum EB21 Approved [5]
Rheumatoid arthritis FA20 Approved [6]
Sarcoidosis 4B20.5 Approved [7]
Ulcerative colitis DD71 Approved [8]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [9]
Therapeutic Class
Antirheumatic Agents
Cross-matching ID
TTD Drug ID
DMQMV1B
VARIDT Drug ID
DR00441

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Not Available [10]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor necrosis factor (TNF) DTT TNF 5.692 3.07 4.413 1.202
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Crohn disease
ICD Disease Classification DD70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor necrosis factor (TNF) DTT TNF 1.24E-17 0.42 1.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Management of inflammatory bowel disease. Med J Aust. 2018 Sep 1;209(7):318-323.
2 Hidradenitis Suppurativa: Advances in Diagnosis and Treatment. JAMA. 2017 Nov 28;318(20):2019-2032.
3 Identification of potential molecular mechanisms and candidate drugs for radiotherapy- and chemotherapy-induced mucositis. Support Care Cancer. 2023 Mar 20;31(4):223.
4 Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis. N Engl J Med. 2021 Apr 1;384(13):1227-1239.
5 An update on adalimumab for pyoderma gangrenosum. Drugs Today (Barc). 2021 Sep;57(9):535-542.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4860).
7 Sarcoidosis-associated acro-osteolysis. BMJ Case Rep. 2021 Mar 2;14(3):e240828.
8 First- and Second-Line Pharmacotherapies for Patients With Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis. Clin Gastroenterol Hepatol. 2020 Sep;18(10):2179-2191.e6.
9 Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. Lancet. 2020 May 2;395(10234):1407-1409.
10 Adalimumab for psoriasis patients who are non-responders to etanercept: open-label prospective evaluation. J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1394-7.