Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRBEZD)

Drug Name

4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one Drug Info

Synonyms

CHEMBL207277; 4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one; BDBM50183665; 2-allyl-4-[(4-chlorophenyl)methyl]phthalazin-1-one; 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-allyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15959119
TTD Drug ID: DMRBEZD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90.