Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRJ5LP)

• Drug Name: Vasoactive intestinal peptide Drug Info
• Synonyms: CCRIS 7231; Vasoactive intestinal polypeptide; Vasointestinal Peptide; Vasoactive intestinal peptide, synthetic porcine; SCHEMBL3041046; GTPL1152; VIP (Vasoactive Intestinal Peptide); LS-174653; VIP

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Phase 2	[1]
Pulmonary arterial hypertension	BB01.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 53314964
  CAS Number: CAS 37221-79-7
  TTD Drug ID: DMRJ5LP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vasoactive intestinal polypeptide receptor 1 (VIPR1)	TTCL30I	VIPR1_HUMAN	Antagonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vasoactive intestinal polypeptide receptor 1 (VIPR1)	DTT	VIPR1	6.594	8.553	6.399	8.394

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 12 Disease of the respiratory system
• Disease Class: ICD-11: CA23 Asthma
• The Studied Tissue: Lung tissue
• The Studied Disease: Chronic obstructive pulmonary disease [ICD-11:CA23]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vasoactive intestinal polypeptide receptor 1 (VIPR1)	DTT	VIPR1	6.47E-01	-0.16	-0.14
Vasoactive intestinal polypeptide receptor 1 (VIPR1)	DTT	VIPR1	4.24E-01	-0.12	-0.26

References

• [1] ClinicalTrials.gov (NCT00464932) Vasoactive Intestinal Peptide in COPD. U.S. National Institutes of Health.
• [2] Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.