Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRKTCP)

Drug Name
Retifanlimab Drug Info
Synonyms MGA012; INCMGA0012
Indication
Disease Entry ICD 11 Status REF
Neuroendocrine cancer 2B72.1 Approved [1]
Non-small-cell lung cancer 2C25.Y Phase 3 [2]
Merkel cell carcinoma 2C34 Phase 2 [3]
Metastatic colorectal cancer 2B91 Phase 2 [4]
Penile squamous cancer 2C81 Phase 1 [5]
Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Cross-matching ID
TTD Drug ID
DMRKTCP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Inhibitor [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Programmed cell death protein 1 (PD-1) DTT PDCD1 5.635 4.661 4.706 5.15
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Neuroendocrine cancer
ICD Disease Classification 2B72.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Programmed cell death protein 1 (PD-1) DTT PDCD1 7.26E-01 -0.01 -0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761334.
2 ClinicalTrials.gov (NCT04203511) INCMGA00012 in Combination With Chemoradiation in Participants With Stage III Non-Small Cell Lung Cancer (POD1UM-301). U.S. National Institutes of Health.
3 ClinicalTrials.gov (NCT03599713) A Study of INCMGA00012 in Metastatic Merkel Cell Carcinoma (POD1UM-201). U.S. National Institutes of Health.
4 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
5 ClinicalTrials.gov (NCT04231981) Efficacy of INCMGA00012 in Penile Squamous Cell Carcinoma (ORPHEUS) (ORPHEUS). U.S. National Institutes of Health.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)