Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRNMKG)

Drug Name

3-methyl-N-(6-methylpyridin-2-yl)benzamide Drug Info

Synonyms

3-methyl-N-(6-methylpyridin-2-yl)benzamide; CHEMBL212724; AC1LJ0IB; Oprea1_323038; Oprea1_123319; SCHEMBL8557860; MolPort-003-351-883; ZINC579315; BDBM50186319; AKOS001316653; MCULE-8428043810; 346720-66-9; ST51016902; N-(6-methyl(2-pyridyl))(3-methylphenyl)carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 966005
TTD Drug ID: DMRNMKG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5.