Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMROP5Q)

Drug Name
Benzothiazole-2-sulfonic acid amide Drug Info
Synonyms
2-Benzothiazolesulfonamide; 433-17-0; Benzo[d]thiazole-2-sulfonamide; 1,3-benzothiazole-2-sulfonamide; BENZOTHIAZOLE-2-SULFONAMIDE; Benzothiazole-2-sulfonic acid amide; CHEMBL168552; CHEBI:34262; 2-BTS; 6-Hydrogen-2-benzothiazolesulfonamide; AC1Q1HM9; AC1L28OQ; SCHEMBL81178; AC1Q55G4; CTK1D5756; DTXSID30195812; MolPort-006-728-089; SDYMYAFSQACTQP-UHFFFAOYSA-N; 3s73; ZINC1847418; ANW-70718; 5987AB; BDBM50160671; AKOS010998801; MCULE-9059575102; EN001332; AM100818; TC-159463; KB-142553; EN300-60766; C14181
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
67944
ChEBI ID
CHEBI:34262
CAS Number
CAS 433-17-0
TTD Drug ID
DMROP5Q

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.