Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRQOL5)

Drug Name

JWH-237 Drug Info

Synonyms

JWH-237; UNII-NR611I7X19; CHEMBL188822; NR611I7X19; 2-(3-chlorophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone; 864445-56-7; JWH 203 3-chlorophenyl isomer; KURUPMPUIIQATM-UHFFFAOYSA-N; ZINC28463001; BDBM50170332; 2-(3-Chloro-phenyl)-1-(1-pentyl-1H-indol-3-yl)-ethanone; Ethanone, 2-(3-chlorophenyl)-1-(1-pentyl-1H-indol-3-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44397713
CAS Number: CAS 864445-56-7
TTD Drug ID: DMRQOL5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 2 (CB2)	DTT	CNR2	7.037	6.733	6.944	7.163

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 2 (CB2)	DTT	CNR2	3.82E-02	-0.43	-1.18

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3.