Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRTHW1)

Drug Name

PHENYLSULFAMIDE Drug Info

Synonyms

phenylsulfamide; N-phenylsulfamide; 15959-53-2; N-phenylaminosulfonamide; aniline sulfonic acid amide; CHEMBL168514; Sulfamide, phenyl-; Sulfamide, N-phenyl-; (Sulfamoylamino)Benzene; N-Phenylsulfuric diamide; SCHEMBL253104; CTK0E6878; DTXSID50574504; DEVUYWTZRXOMSI-UHFFFAOYSA-N; MolPort-030-912-022; ZINC13488090; BDBM50124170; AKOS029900887; 79499-EP2305698A2; 79499-EP2305697A2; 79499-EP2305695A2; 79499-EP2305696A2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15569631
CAS Number: CAS 15959-53-2
TTD Drug ID: DMRTHW1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500.