Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS4P6K)

Drug Name

Biostrophin Drug Info

Synonyms

Duchenne muscular dystrophy therapy, Asklepios; Adeno-associated virus gene therapy (dystrophin), AskBio; Adeno-associated virus gene therapy (dystrophin), Asklepios

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMS4P6K

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dystrophin (DMD)	TT48MP6	DMD_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dystrophin (DMD)	DTT	DMD	6.356	5.446	5.459	5.326

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Duchenne dystrophy

ICD Disease Classification

8C70

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dystrophin (DMD)	DTT	DMD	1.15E-07	-1.07	-2.94

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023141)
2	Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches. Nat Rev Genet. 2013 Jun;14(6):373-8.