Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS7DA3)

Drug Name

8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info

Synonyms

CHEMBL134057; 8-chloro-1,2,3,4-tetrahydroacridin-9-amine; 122994-74-5; 8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine; SCHEMBL9584574; MolPort-039-242-295; ZINC27416388; BDBM50279984; AKOS033887449; 9-Amino-8-chloro-1,2,3,4-tetrahydro-acridinium

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 19770285
TTD Drug ID: DMS7DA3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992).