Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSA6IY)

Drug Name

arecaidine propargyl ester Drug Info

Synonyms

Arecaidine propargyl ester; 35516-99-5; NCGC00015006-01; Lopac-A-140; AC1L1D7L; AC1Q62JO; Lopac0_000136; GTPL295; CHEMBL128365; SCHEMBL13184690; CTK1B6885; CHEBI:92418; DTXSID30274358; SPHRJZBOFYIKMC-UHFFFAOYSA-N; prop-2-ynyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate; 2-Propynyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate; ZINC25720839; AKOS030566155; CCG-204231; NCGC00015006-03; NCGC00162072-01; NCGC00015006-04; NCGC00162072-02; NCGC00015006-02; L000114; BRD-K23922020-075-01-1; prop-2-ynyl 1-methyl-5,6-dihydro-2H-pyridin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2229
ChEBI ID: CHEBI:92418
CAS Number: CAS 35516-99-5
TTD Drug ID: DMSA6IY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor (CHRM)	TTOXS3C	NOUNIPROTAC	Agonist	[2]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 295).
2	Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9.